There are four studies conducted under this program namely RIO-Europe, RIO- North America, RIO- Lipids, and RIO- Diabetes. Every program has specific goals and objectives. To have an overview of the methods and specifications of the program, read on the following details below.

The RIO- Europe included one thousand five hundred and seven (1507) participants. The study was conducted for one year. The RIO- North America included three thousand and forty five participants in the study. It was held for two years. It had the longest period among all the RIO programs.

To qualify for the RIO- Europe and RIO- North America Study, one has to have a BMI of at least 30 kg/m2 or 27 kg/m2 for patients with comorbidity.

RIO-Lipids study was also conducted to test the effect of the drug on the fat content of the body. It employed one thousand and thirty three participants. The study was one year long. The BMI of the participants are between twenty seven to forty kg/m2. The BMI requirement is important so that the study can examine the effect of the drug on weight reduction as well. To be eligible for the study, one has to have dyslipidemia.

RIO- Diabetes program, on the other hand, was intended to test the effect of the drug on blood sugar level of a person. One thousand and forty five participants were included in the study, which is held for one year. To be eligible for the study, one has to have untreated type 2 diabetes. The participants should have between twenty seven to forty kg/m2. The BMI requirement was needed to examine the effect of the drug on weight as well. People who are taking medication for diabetes were not allowed to join the study. Through out the study, the participants did not take other medication other than the rimonabant drug.

All of the programs were randomized and double blinded. It is done through giving placebo pills, 5 milligram and 20 milligrams rimonabant pills separately to randomly chosen individuals. Through out the study, people underwent hypocaloric diet to make the effect of the drug better. People with history of psychological and mental disorders were not allowed to participate in the study.

The areas of assessment are weight, waist circumference, and metabolic risk factors. Effects on psychological condition were assessed through Hospital Anxiety and Depression (HAD) scale. The side effects of the drug were also the main concern of the authors of this study.

The individuals were given the opportunity to discontinue or continue the experiment at their own will. In case they do not feel comfortable with the drug, they are allowed to stop their participation to the study.

The result of the study was analyzed through comparing the performance of the individuals who took placebo pills with the individuals who took small and large dozes of rimonabant drug. Significant differences were noted to determine the effectiveness and side effects of the drug.

The overall result of the studies showed reduction in weight and the waist circumference. The RIO- Lipids study showed favorable effects as well. Study on effect of the drug on diabetes showed positive results too. The metabolic risk factors were also improved.

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